It is the dominant team of the competition.

Playing on enemy asphalt, the Kookaburras handed ladder leader East Point its first defeat of the year.

After a tight opening quarter, Sebastopol turned up the heat to triumph 67-44.

Players had not expected a blow-out to be the result of the match they had so eagerly anticipated.

"It was the game we were waiting for," Sebastopol captain Emma Bryant said.

"But we didn't expect to win by that margin. We were quite nervous, but we just worked hard at it. Our aim was to get a few goals up in the first quarter, and try and break away from there."

The victory put the Kookaburras on the top-rung by percentage, and boosted their confidence going into Sunday's clash with Lake Wendouree.

Catherine Maika shot 51 goals for the match, reaping rewards for consistently leading to the ball.

Her agility, experience and pairing with fellow shooter Erin Firns seemed to floor the East Point defence, which lacked energy and passion.

It suffered a further setback when Kathryn Murphy left the court with a knee injury in the final quarter.

It was up to Kate Byrne to rally East Point's flagging spirits, and she responded with 37 goals of her own.

Sam Denouden also shot well in the absence of Peta Fisher, while centre Katie Williams provided steely drive up the court.

However, Sebastopol's Chelsea Snibson and Lucy Leeming foiled too many of the Kangaroos' goaling attempts, and wing attack Stacey Wood created countless opportunities.

East Point will look to redeem itself against Sunbury on Sunday, but will need to produce one of its cleanest performances.

Lake Wendouree tied with Redan, and Melton South easily accounted for Darley.