A 55-year-old man was left with serious injuries after he was punched in a Fitzroy street on Friday night, police say.
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The man fell and hit his head on the road at the corner of Smith and Webb streets about 8pm, a police spokesman said.
Senior constable Adam West said there had been an altercation between two groups of people who had just left a nearby pub.
"Two men, a 21-year-old and a 25-year-old from Brunswick West were arrested and are assisting police with their enquiries," senior constable West said.
The 55-year-old man was taken to the Royal Melbourne Hospital in a serious but stable condition, an Ambulance Victoria spokesman said.