St Kilda Road, Spring Street, Flinders Street, Harbour Esplanade and Brunton Avenue will be closed from 6pm on New Year's Eve until at least 1am in a bid to keep pedestrians safe.

Extra bollards will be placed around the city while 1000 police officers, including uniform and plain-clothed members, the Air Wing, Mounted Branch, Water Police and Critical Incident Response Team will be out in force.

It's understood police vehicles will also be used provide a ring of defence around the city and Docklands, as a further 1000 officers dedicated to New Year's Eve activities will be placed around the state.

"We'll basically lock down the centre of the city," Deputy Commissioner Andrew Crisp said on Friday. "I won't go into tactics or our specific operational activities, but we will have layers of protection in place in the city.

"What will become visible to people coming into the city is additional concrete bollards, which will better protect those people who will congregate in the main area of Flinders and Swanston streets.

"That is our final ring of security but every police member out there in uniform is someone you can go to if you see something or hear something is suspicious."

Police confirmed they had no evidence of an immediate terror threat but urged Victorians to remain alert.

Premier Daniel Andrews on Friday asked Victorians to be undaunted by recent events, including last week's Flinders Street tragedy and the arrest of a man in November over a New Year's Eve terror plot.

"We won't be defined by these tragedies, as impactful as they are, as much as they hurt. Everyone has a heavy heart when they think about what happened last week, but we're not going to be cowed by this."

"At the same time though, we are alert to the dynamic threats in great cities all around the world."

The celebrations will be the largest in Victoria's history, including 68 pyrotechnicians lighting 14 tonnes of fireworks from 22 rooftops around the city, to the total tune of $2.8 million.

Acting Lord Mayor Arron Wood called it "money well spent", adding Sydney would only have eight tonnes of fireworks.

"The important thing to note is in that, just over $500,000 is fireworks. The rest of that is all about the logistics and safety and planning for this huge event."

"The New Year's Eve fireworks will be our biggest ever. It's going to be an absolutely spectacular evening."

Viewing sites Kings Domain, Treasury Gardens, Flagstaff Gardens and Docklands will have live entertainment from 9pm while family-friendly fireworks scheduled for 9.30pm will take place at Yarra Park and Footscray Park.

An additional 100 train services will also be put on to help carry an extra 50,000 people into and out of the city.

On the issue of rampaging youths who marred New Year's Eve celebrations two years ago, Mr Crisp said African and Pacific community leaders would be on city streets with officers.

Ambulance Victoria state commander Paul Holman also urged Victorians to look out for each other and avoid drug and alcohol-fuelled injuries.

"Unfortunately for us, it's the busiest night of the year. We do more cases, particularly between midnight and 5am, than any other time of the year," Mr Holman said.

"There is a section of the community who doesn't listen to the warnings, who don't listen to the emergency services, and they go out there and they play up and they get into trouble.

"The end result is, instead of spending New Year's Eve with their mates or their families, they usually spend it with us or in a hospital."

For more New Year's Eve information, visit the City of Melbourne website.