That local trifecta in the top half of the men's draw feature in the second round on Wednesday. Millman, 28, faces the trickiest match against Damir Dzumhur, the world No.30 from Bosnia and Herzegovina.

In the women's draw, Daria Gavrilova confronts Belgian Elise Mertens and Olivia Rogowska meets lowly ranked Ukrainian Marta Kostyuk after taking the points in all-Australian first round match against Jaimee Fourlis.

Ebden, Australia's second-ranked player who made the biggest leap up the ATP Tour rankings in 2017 - from 699 to 78 - confronts someone he hasn't played before, Ukraine's world No.38 Alexandr Dolgopolov.

Kyrgios is a red-hot favourite against Serbia's Viktor Troicki.

Ebden, 30, has never previously reached the third round at a slam and last played the second round at a major at Wimbledon three years ago.

Already he's on a giant-killing run in 2018, his elimination of the tournament's 16th seed John Isner on Monday coming after he pushed eventual champion Kyrgios all the way at the Brisbane International before defeating world No.6 Marin Cilic in three sets at last week's Kooyong exhibition tournament.

The West Australian had a rugged 2016 when a knee issue sidelined him for six months, but his hot form sees him firm for a Davis Cup singles role alongside Kyrgios.

He sees the positives from his injury lay-off.

"Even in the last six to eight months, I've probably taken another step, and I'm playing at the best level in the game, one of. I've matched it or beaten some top 10 guys, matched it with other top 10 guys, been very close with a lot of these guys," Ebden said.

Countryman Millman will be out to match his third round berth at last year's US Open, a marker he also reached at Melbourne Park in 2016 and at Wimbledon later than same year.