Maryborough Police along with Central Goldfields Crime Investigation Unit detectives shut down an alleged hydroponic crop house in Bowenvale, near Maryborough, on Friday.
Police executed a search warrant at the Timor Road home about 10am.
A large number of cannabis plants were seized along with hydroponic equipment at the house.
A 58-year-old Bowenvale man was arrested at the scene and is currently assisting police with their enquiries.
The investigation is ongoing.
Anyone with any information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential crime report online at www.crimestoppersvic.gov.au.