After two Kynteton men were killed Saturday night at Lancefield, another two people were killed on Sunday, one at Daisy Hill, near Maryborough and another on the Midland Highway near Lethbridge.

A man in his 70s died after a two car head-on collision on the Ballarat-Maryborough Road at 10.45am.

It is understood a Holden sedan veered onto the wrong side of the road and crashed into a Ford station wagon. 

An Ambulance Victoria spokesperson said the driver of the station wagon, a man in his 80s, was airlifted to hospital in a serious, but stable condition, with chest injuries. A woman, also travelling in the station wagon, suffered cuts, abrasions and shock and was also airlifted.

Less than three hours later emergency services were called to another fatal collision, this time on the Midland Highway at Lethbridge at 1.20pm after reports of a crash between a truck and a car.

The driver of the car, believed to be a man in his 60s, died at the scene. His passenger, believed to be a woman in her 60s, suffered serious injuries and was airlifted to hospital.

The driver of the truck was not injured with police spending much of the afternoon piecing together what took place. Traffic on the Midland Highway was diverted through Steiglitz. 

Meanwhile, two Kyneton men died after a crash at Lancefield on Saturday evening.

Investigators have been told a ute was travelling along Rochford Road just before 7pm when it crashed into a tree near Collivers Lane.

Two passengers, a 31-year-old man and a 36-year-old man from Kyneton, died at the scene, while the driver, a man in his 40s from Newham, was airlifted to hospital with life-threatening injuries.

Detectives from Major Collision Investigation Unit are investigating all of the crashes

Meanwhile, two females were taken to Ballarat Base Hospital after a two-car crash near the corner of Humffray Street South and Barkly Street in Mount Pleasant on Friday night.

A teenage girl and a woman in her 30s were both treated for leg injuries and were taken to hospital in a stable condition.

Victoria's road toll now stands at 70, 22 more than at the same time last year. 

Police are seeking any witnesses to come forward by contacting Crime Stoppers on 1800 333 000.

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