Update, 10pm: The Western Highway has been re-opened on both sides of Ararat, following two separate collisions earlier today.
In a statement, VicRoads thanked drivers for their patience during the disruption.
For the latest traffic information around the state, click here or download the VicTraffic app via your app store.
Earlier: The region's horror start to the Easter period on the roads has continued, with emergency services attending an accident in the middle of Ararat which left a six-year-old with a potential broken arm.
The two-car collision occured about 3.10pm on Vincent Street.
Earlier, about 1.30pm, a car ran into a tree on Warrayatkin Road, Ararat.
Police reported that a 33 year old woman is trapped in the vehicle but the two children also in the car have been freed.
This follows attending a head-on collision on the Western Highway near the Caltex Roadhouse in Dobie, east of Ararat.
The head-on was the result of a three car collision, which cannoned a vehicle on to the incorrect side of the Western Highway where it crashed in to an oncoming car headed toward Ballarat.
A woman in her 30s was trapped in her car after the crash, which occurred about 11.50am.
After being freed the air ambulance flew the woman to the Alfred Hospital in Melbourne with head, arm and chest injuries.
A second person, who paramedics assessed at the scene, was taken via road ambulance to Ballarat Base Hospital with ankle injuries.
Police said two vehicles had been travelling west in congested traffic when a third car came over a slight rise and collided with those two vehicles, causing a nose-to-tail collision. The third vehicle then veered in to oncoming traffic.
The occupants of the Ballarat-bound vehicle, a man and a woman, were both taken to hospital with serious injuries. The male driver of the third car was taken to hospital with non-life threatening injuries.
The Dobie accident follows a fatal crash early this morning at Armstrong, about 20km away, where a man died and two were taken to hospital.
Another serious crash happened on the Western Freeway this morning involving a family of seven, while in Beaufort, another minor incident occurred on Raglan Road about 3pm.
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