Speeding was a prevalent issue in the Ballarat region, according to statistics from Operation Nexus, with more than 140 drivers caught breaking the law over the five day operation which finished on Monday.

More than 3000 preliminary breath tests were completed by police in the area, with five people caught drink-driving in Ballarat and ten people found to be driving while affected by drugs.

Speaking from the scene of a fatal crash at Navigators on Tuesday, Acting Senior Sergeant Stuart Gale said the region saw "a lot of offending", particularly when it came to not obeying speed signs and driving while impaired.

A 46-year-old Creswick man died when his cement truck went down an embankment and rolled on Navigators Road at 10.30am. Police believe speed may have been a factor in the crash.

"We put out a lot of messaging around this, and to see those sort of results and the message not getting through, it's disappointing," he said. "Since 2013, we've seen drugs taking over from alcohol in our serious injury and fatality crashes. In trauma, it's factoring incredibly high.

"The results for the weekend speak for themselves ... it's just not acceptable."

Across Victoria, on average one in every 16 drivers that were drug tested were found to be under the influence of illicit substances, with 310 people returning positive results for drugs while driving.

Thirteen people were caught in the Ballarat area not wearing seatbelts.

Across the state, three people died on the road, including a 55-year-old South Australian man who died on Friday morning at Armstrong, near Ararat.

Road Police Command Assistant Commissioner Stephen Leane said in a press conference a strong police presence would continue over the Anzac Day public holiday period, as they "ensure the tragedies we have seen during Easter are not repeated".

"Three people's families have had their lives irreversibly damaged this weekend," he said. "Every driving offence, be it speeding, drink or drug driving, or failure to wear seatbelts, can take a life in a split second."

The Victorian road toll now stands at 102 lives lost since the beginning of 2019, more than 65 per cent worse than this time last year.