Bendigo Bank is on the move from its high-profile branch on the corner of Sturt and Doveton streets in the centre of the city.
For sale or lease signs were erected last week as the bank looks to move to a new location within the CBD.
A Bendigo Bank spokesman confirmed there were no plans to close the Ballarat branch.
Ray White Real Estate is selling the two-level building, which has large meeting areas upstairs in addition to the bank facilities on the ground floor.
The real estate advertisement says the expansive property "offers massive exposure making it ideal for either high end retail or restaurant/cafe uses".
The bank plans to move at the end of spring, with the agency offering vacant possession to occupy from October/November this year.
It is rumoured the branch could be moving across the intersection in to the old Banksia building on the north eastern corner of the crossroads.
The sale of the Bendigo Bank building brings to nine the number of buildings for sale along Sturt Street in Ballarat Central, with other properties up for sale including the Unicorn Hotel, as well as retail outlets, historic buildings and offices.
In a welcome sign for Ballarat city retailers, two well-known brands have announced they are opening stores in Central Square next month.
Celebrity pyjama designer Peter Alexander Sleepwear will bring his trademark pink-hued store fitout to the ground floor of the CBD shopping centre, with fans on social media welcoming the news.
And high-end accessories retailer Mimco will also open in Central Square in July, bringing their range of handbags, purses, scarves and shoes to the Ballarat shopping scene.
The two newcomers join women's fashion chain Witchery, which opened in Central Square in April.
The movement among Sturt Street retailers comes a month after City of Ballarat announced plans to re-open Bridge Mall to traffic as a way to boost visitation and business in that part of the city.
The vacancy rate in the mall now stands at 17.6 per cent according to council statistics, which represents an almost three-fold increase since 2012.
Traders welcomed the plans, which involve a proposed $15 million renovation, as a way to bring more customers in to the mall.
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