Frontline staff in Victoria's hospitals will have compulsory vaccinations under a new set of rules developed by the state government.
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The new rules will mean it is mandatory for nurses, doctors and other staff to be fully vaccinated against a number of diseases, including the flu.
High-risk parts of hospitals such as intensive care units, neonatal intensive care units and cancer wards will become areas that require all staff to be vaccinated.
Workers who refuse vaccinations will be moved to other parts of the hospital.
Minister for Health Jenny Mikakos said the government has been working with health experts, unions and hospitals in developing the new rules.
"There's no doubt about it - vaccinations are safe, effective and save lives," she said.
"That's why we're taking action to make sure health workers and patients are protected against dangerous diseases."
The state government already makes the flu shot free for healthcare workers.
Ms Mikakos said this year's flu season put enormous strain on nurses, doctors and paramedics.
More than 70 people have died from flu this year with 40,000 laboratory-confirmed case of flu reported across the state including 10,000 cases in children.
"The flu season has hit Victoria hard but our hospitals and paramedics have done an exceptional job rising to the challenge," Ms Mikakos said.
"It should give all Victorians confidence that they're in the very best hands."