A police media spokesperson confirmed two men in a van were taken to hospital after a collision near Stoneleigh involving a truck.
A 79-year-old man was airlifted to Melbourne, while a 66-year-old man was taken to St John of God Hospital in Ballarat.
The truck driver was not injured.
UPDATE: One man has been airlifted to The Alfred Hospital with upper body and foot injuries after a crash at Stoneleigh this afternoon.
Ambulance Victoria said the man, whose age has not been released, has been airlifted in a stable condition.
A second man aged in his 60s also involved in the crash, has minor injuries and was taken by road to St John of God Hospital in Ballarat also in a stable condition.
EARLIER: An air ambulance is on the way to a serious crash north-west of Skipton.
The crash, at the intersection of Eurambeen-Streatham Road and Mount William Road, Stoneleigh, happened just after noon.
It is understood one person may be trapped in a vehicle at the scene, but at this stage their condition is not known.
Drivers are urged to avoid the area if possible for the immediate time.
Meanwhile, emergency services were called to Delacombe about 12.40pm after a minor crash. One person has been taken to hospital for observation.
More to come.
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