Film crews were hard at work on Lydiard Street on Wednesday afternoon, frantically putting up signs to begin transforming it into 1947 Boston.
The film, Road to Boston, tells the true story of Korean athlete Suh Yun-bok's win at the Boston marathon in 1947, and several Victorian cities are being used as backdrops.
This week, crews from the South Korean and Australian co-production took over the Ballarat airport to film sequences, before moving to Lydiard Street on Wednesday and Thursday.
The street will be closed from 6am to 7pm on Thursday, with parking already restricted.
On Friday, Camp Street will be closed from 2pm, while parts of Bakery Hill on Humffray Street and Main Road will be closed on Saturday.
All businesses will remain open, with pedestrian controllers on-site, though parking will be restricted.
About 150 extras will run the course, filmed with a camera crane on a tracking vehicle and a camera drone.
Scenes have also been filmed in Geelong, and will later move to Bendigo and Williamstown.
Ballarat's historic buildings and wide streets made it a perfect choice, art director Adele Fleve said, though there'll still need to be some classic cars, American-style street signs, and more touches to be installed to make it look right.
"There's specific reference to certain streetscapes, geographically how they turn and move, and that's what we're matching," she said.
"Today, we're covering inappropriate, period incorrect signage with our 1947 signage to make it look like Boston.
"Obviously there's quite a few things we can't do, but that's taken care of with CGI elements - anything over three metres high is dealt with that way."
Ms Fleve, who has shot in Ballarat previously for The Doctor Blake Mysteries, said the aim will be to make it not look like Ballarat at all in the finished product.
"It'll be intercut with a lot of things, so we will hope it won't look like Ballarat," she said, laughing.
"A lot of stuff we're shooting from a drone, so we will see quite a lot, but obviously, we're supposed to look like Boston."
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