This will be the first long weekend for Victorians since some social restrictions put in place to limit the spread of coronavirus have been lifted.

As Victorians prepare to leave the walls of their homes with loosened social restrictions meaning overnight stays and social gatherings of up to 20 people are allowed, while some pubs and restaurants have reopened with a limit to serve up to 20 people, police will be out in force to prevent an increase in road trauma.

According to statistics from the Transport Accident Commission, 97 lives have been lost on the state's roads this year.

While it is a decrease of 27 per cent on the number of deaths on Victorian roads at this point in 2019, it is not far behind the number of lives lost to the deadly coronavirus across the nation.

While Victorians have adhered to public health warnings to limit the spread of the deadly virus, police are now urging Victorians to adhere to road safety warnings with the same seriousness.

The five major contributors to road trauma include speeding, drink and drug driving, fatigue, distraction and failing to wear a seatbelt.

All will be focuses for police this long weekend, with local highway patrol units to be assisted by general duties and other operational units.

Ballarat Highway Patrol's Acting Senior Sergeant Stuart Gale urged people to be careful on the roads this weekend.

As some people may be travelling long distances to go away for the weekend, he urged people to take extra caution as they may be out of practice due to weeks of remaining at home.

"Our message to people is to be careful out there this weekend," he said.

"If you are driving, you may not be used to being behind the wheel after a period of time at home so prepare, plan and stay alive."

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Road Policing Command's Assistant Commissioner Libby Murphy urged people to take road trauma seriously as one life lost was one too many.

"I ask that you make the smart decisions when on the road," she said.

"If nothing else, think about the grief and sadness your loved ones will have to go through should you not make it home, or the pain they will have to endure visiting you in a jail cell from killing someone else."

Operation Regal will run from 12.01am Friday, June 5, until 11.59pm Monday, June 8.

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