A 48-year-old Napoleons woman, who was a passenger to an 18-year-old driver, died when they were involved in a two-car crash on the Ballarat-Colac Road just after 8pm on Sunday

The drivers of both vehicles, including a 43-year-old from Enfield, were taken to hospital as a result of the crash with non life-threatening injuries.

Police spent much of Monday on the scene piecing together the tragic events of the previous night with a number of factors including distraction, inattention, speed and driver experience among those being investigated.

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"We've now seen two fatalities in a very short space of time. These are very tragic incidents," Senior Sergeant Stuart Gale said.

"Distraction and inattention are the key message here. We implore people to concentrate.

"Country people die on country roads, and more often than not, it's close to home.

"We need to be courteous on the roads and reduce your speed. Speed is a factor due to the trauma it causes."

Senior Sergeant Gale said police were concerned that they are seeing more major trauma in recent weeks.

"We do hold some significant concerns," Sergeant Stuart Gale said.

"We saw a trend of an increase in trauma the last time we came out of lockdown and we are seeing this again. This is the second life lost on our roads in the past two weeks. I implore the public to please take care on the roads. We're going to see wet weather for a week or so and now people have freedom."

Senior Sergeant Gale said historically October was one of the worst months on the road due to changing weather conditions and more people out and about.

He said there was constant messaging around safety on the roads and it was up to all drivers to be aware of their surroundings.

"We need to concentrate on our roads, driving a motor vehicle at speed can be a tragic combination," he said.

"We saw a horrible year last year, please let's not see that again heading into Christmas."

TAC Head of Road Safety, Samantha Cockfield said any death on our roads is a preventable tragedy.

"We know the roads will get busier as restrictions continue to gradually ease, and it's so important that we are vigilant and well prepared."

"We don't accept that more traffic should inevitably result in more road trauma, and we're asking people to take extra precautions on our regional roads - slow down, don't drink and drive, avoid distractions, and avoid driving tired."

Acting Sergeant Ryan Newman, from Daylesford Police Station has attended two serious crashes in recent weeks.

While traffic, serious injury and fatality collisions have decreased due to restrictions put in place, police are preparing to focus more on road safety with the onset of spring and the likelihood restrictions will ease soon.

"We have certainly noticed that there is a larger amount of traffic on the road due to the nice weather and people choosing to get out and about," Acting Sergeant Newman said.

"As the restrictions reduce, we're expecting more people to be on our roads. It is an area that we will pay close attention to - speeding, driver inattention, distraction and drink and drug driving."

Anyone who witnessed Sunday night's crash is urged to contact Crime Stoppers on 1800 333 000.

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