Starting Tuesday, buses will replace V/Line trains on the Ballarat, Ararat, and Maryborough lines for 11 days.
Services should resume from the first service on Saturday, May 8 - passengers should allow more time to get to and from Melbourne.
Crews will carry out maintenance and major upgrades to bridges and stations, according to a Department of Transport media release.
The focus will be upgrading Melton station, with a new footpath, CCTV, parking spots, and shelters to be installed.
Elsewhere, rail milling, track and signaling work, bridge deck replacements, and level crossing maintenance will be completed.
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More works will lead to train replacement buses next month, between May 12 and May 20.
The disruptions follow the major $500 million Ballarat Line Upgrade, completed in February, which included new passing loops and stations, as well as a more frequent timetable.
Keep an eye on the timetable changes at V/Line's website.
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