Ahead of his return on Monday, Mr Andrews and wife Catherine released a video on social media explaining how he slipped and fell while getting ready for work at a Mornington Peninsula holiday rental on March 9.

"As I put my foot on to the first step. I knew I was in trouble. I didn't really connect with the step it just slid straight off, I became airborne almost," Mr Andrews says in the four-minute video.

Watch the video here.

"Then all I can hear is just this almighty crunch.

"When I heard the crunch, I knew. I thought this is serious, we're in trouble here."

Mr Andrews said he couldn't call out to his wife because he couldn't breathe. She found him moments later.

"It was awful because you were going blue, and we were looking at each other and I was thinking, you are going to die here in Sorrento at this holiday house," Ms Andrews said in the video.

"You're looking at me and you felt the same."

The couple thanked those involved in Mr Andrews' recovery, including his personal protective detail, paramedics, doctors, nurses and physios.

He also thanked Victorians for their well wishes and confirmed his plans to run at the 2022 election.

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"I'm running and I'm running to win. There's unfinished business and I'm determined to get it done," Mr Andrews said.

His deputy James Merlino has been acting premier in his absence, steering the state through a fourth COVID-19 lockdown which left Victorians weary and cost their economy an estimated $1.3 billion.

Opposition Leader Michael O'Brien has questioned Mr Andrews' return date, amid school holidays and a six-week winter break for parliament.

"People will be a little bit cynical about the fact that he only comes back when parliament's shut down the next five or six weeks," he told reporters last week.

"It would have been better for Victorians and better for democracy if the premier had been here this week to answer questions about our fourth lockdown, and why Victoria alone has had four lockdowns."

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