Melbourne City will play their first competitive match since winning the A-League Men grand final when they face former NSL powerhouse South Melbourne in their FFA Cup round of 32 clash on November 12.
Cup fixtures have been postponed due to coronavirus outbreaks in NSW and Victoria but increased vaccination rates and plans to open up have enabled games to be rescheduled.
South Melbourne will host City at Lakeside Stadium - a week before the ALM season starts on November 19 - in one of the Cup's most anticipated clashes.
The round of 32 and round of 16 in this year's competition sees teams divided into regional zones, in a bid to limit the effect of border closures on the early rounds, before the competition opens up in the quarter-finals.
Other major games include Broadmeadow Magic hosting Western Sydney on November 10 and Sydney Olympic hosting Sydney FC on November 24.
Newcastle Olympic welcome Cup debutants Macarthur FC on November 13, the same day Blacktown City are due to host Central Coast in Mudgee, subject to restrictions easing between Greater Sydney and regional NSW.
In the round of 16, holders Adelaide United will continue their Cup defence on Sunday when they face Adelaide Olympic, while Lions FC will host Brisbane Roar on October 24.
Due to border closures, the round of 32 clash between Victoria's Avondale FC and Tasmania's Devonport Strikers will be confirmed at a later date.
Playoff matches between Perth Glory and Melbourne Victory and Newcastle and Western United are still yet to be scheduled.
Last year's FFA Cup was cancelled.
ADDITIONAL CONFIRMED ROUND OF 32 MATCHES (AEDT)
* Mt Druitt Town Rangers FC v Wollongong Wolves FC at Popondetta Park, Saturday 6 November, 7pm
* Hume City FC v Port Melbourne Sharks SC at ABD Stadium, Wednesday 10 November, 7.30pm
* Broadmeadow Magic v Western Sydney Wanderers at No.2 Sportsground, Wednesday 10 November, 7.30pm
* South Melbourne FC v Melbourne City at Lakeside Stadium, Friday 12 November, 7.30pm
* Blacktown City FC v Central Coast Mariners at Glen Willow Stadium, Saturday 13 November, 5pm
* Newcastle Olympic v Macarthur FC at No.2 Sportsground, Saturday 13 November, 6pm
* Tigers FC v APIA Leichhardt at Viking Park, Wednesday 24 November, 7.30pm
* Sydney Olympic FC v Sydney FC at Belmore Sports Ground, Wednesday 24 November, 7.30pm
Australian Associated Press