Premier Daniel Andrews on Friday confirmed travellers will no longer need to quarantine either at home or in hotels if they are fully vaccinated and test negative to COVID-19 before their flight and then 24 hours after arrival.

The change will come into effect on November 1, the same day as NSW.

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"No hotel quarantine, no iso - you'll be able to go about your business," Mr Andrews told reporters.

"And the reason for that is that at 80 per cent, 90 per cent (fully vaccinated) - which is where we're going to get to - we are as protected as we can be."

Children aged under 12 and those with a medical exemption will also not be required to quarantine.

About 250 unvaccinated people will be able to return each week but will need to quarantine at a hotel for 14 days.

Victorians have been warned COVID-19 case numbers could hit fresh highs as Melbourne reopens after its sixth lockdown.

With stay-at-home orders repealed from Friday, Chief Health Officer Brett Sutton said infections would likely rise and urged people to follow check-in and mask rules.

"There will be more COVID in the community really than at any other point in time," he told reporters.

Of more than 23,000 active cases in the state, 784 are in hospital battling COVID-19 including 145 in intensive care.

Some 88 per cent of COVID-19 patients in hospital are not fully vaccinated, while 94 per cent of those in ICU are not double-dosed.

Premier Daniel Andrews said further boosting vaccination rates would be crucial to protecting the health system.

"Those numbers tell you the story. They tell you the only story you need to know: if you get vaccinated, you will not finish up in hospital," he said.

Mr Andrews confirmed Victoria is poised to pass its 80 per cent full vaccination target next weekend, prompting further easing of restrictions.

"We will be out quite soon to clarify what we hope can happen at the end of next week," he said.

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