A medical transport plane with three crew members on board has gone missing in Hawaii on a flight between Maui and the Big Island.
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"Global Medical Response can confirm that one of our Hawaii Life Flight emergency fixed-wing airplanes based in Maui went off radar while en route to pick up a patient in Waimea, Big Island," the company said in a statement on Friday.
The patient was not on the plane, which lost radar contact about 9.30pm Thursday, it said.
"We are in the process of reaching out to their families," the statement said.
The company is also assisting search and rescue teams.
The Coast Guard said aircraft controllers lost radar contact with the plane about 27 kilometres south of Hana, Maui, in the Maui Channel of the Pacific Ocean.
The Coast Guard says it is searching with boats, a helicopter and a cargo plane.
The guard said one of its aircraft spotted a sheen in the search area.
It also reported one of its patrol boats recovered debris in the area but it said there was no confirmation that it was from the missing plane.
Global Medical Response said it has temporarily paused Hawaii Life Flight transports, prompting Governor Josh Green to issue an emergency proclamation allowing the state to supplement Hawaii's medical flight capacity in the interim.
The proclamation allows the Hawaii National Guard to fly Blackhawk helicopters to transport patients.
It will also allow AirMed International, a sister company of Hawaii Life Flight, to bring a plane and crew members to Hawaii from the United States mainland.
Many hospitals on Hawaii's more rural islands are small and offer limited medical services compared to Honolulu's larger hospitals.
Patients with more serious, urgent conditions often need to be transported to Oahu for care.
Green, a physician who worked as an emergency room doctor on the Big Island before becoming governor this month, spoke from personal experience about the importance of the flights.
"I'm very familiar with this having for decades cared for patients and relied on this extraordinary service when someone's had a big heart attack or there's been a terrible accident," he said at a news conference.
He said typically 10 to 15 patients a day are transferred between islands.
Australian Associated Press