Sarah Ristevski, 21, told 3AW she had reached out to her mother's friends on Facebook but to no avail.

"There's no leads at all, no sightings, nothing," she said. "I've logged onto her Facebook and contacted all of her friends. No one has seen her."

Sarah said she was desperate for her mother to return home.

Ms Ristevski, 47, has been missing since Wednesday.

She was last seen at her home in Oakley Drive, Avondale Heights, about 10am.

Police are focusing their search on an area of parkland in Avondale Heights, near a walking track to the rear of her property, which backs onto the Maribyrnong River, where Ms Ristevski is known to walk regularly.

It has been reported she went for a walk to "clear her head" after an argument with her husband, Borce, over financial issues. The couple own Taylors Lakes formal wear business Bella Bleu.

Senior Constable Adam West said police have grave concerns for Ms Ristevski's because her disappearance was out of character.

Her mobile phone is switched off and she has not used her debit card.

At the time Ms Ristevski went missing, she was wearing a black jacket and dark pants. She has shoulder-length dark hair, is about 160 centimetres tall and has a slim build.