Drummond Street has been set for a major redevelopment in an effort to make it safer for pedestrians.
The VicRoads-owned thoroughfare will be reshaped with a median strip and zebra crossings between Sturt and Webster streets.
There have been 10 crashes, resulting in 17 injuries along the hospital strip in the past five years.
VicRoads will also investigate lowering the speed limit to 40km/hr to further improve safety.
The crossing between Mair and Webster streets will also be relocated under the plan.
VicRoads’ acting regional director Mal Kersting said Dummond Street had a history of crashes.
“These works are part of a major upgrade to Ballarat's cycling and walking paths, to make it safer and easier for pedestrians and cyclists to get around the city,” he said.
“The proposed median strip and zebra crossings will provide a safe refuge for pedestrians trying to cross this busy street."
The plans for Dummond Street were part of a city-wide overhaul of cycling and pedestrians routes across Ballarat.
It included changes to Sturt Street, between Dawson and Grenville streets and Gillies and Pleasant Street.
No parking will be affected on Drummond Street, with enough room available to accommodate current car parks and the proposed media strip.
Residents can view the proposed changes on the engage VicRoads website.
They can also leave their comments and thoughts on the redevelopment. The entire city-wide project will cost $9.3 million and aims to accommodate the predicted 36 per cent increase to Ballarat’s population by 2036.
The plans include more than 12 kilometres of upgraded walking and cycling paths across the city.