Hepburn blitzed arch-rivals Daylesford with a powerful opening round display on Saturday.
The Burras shook off a determined Bulldogs side after quarter time to record a convincing 92-point victory on home soil.
McKay brothers Andy (five goals) and Brad (best on ground) tore it up for Hepburn, while new recruits Tommy Horne, Sam Dunstan (four goals), Nathan Dunstan (one goal) and Julian Lockwood (three goals) all featured among the leading players.
Over at Rokewood, the Grasshoppers landed a memorable round one success against Learmonth.
The new-look outfit kicked right away from the Lakies after half time - booting seven goals in the final term - to land a 78-point win.
There was also a bit of a shock at Sebastopol's Marty Busch Reserve where Bungaree got the job done against 2018 Central Highlands Football League grand finalists Buninyong.
The Demons prevailed in a low-scoring affair by 17 points.
Buninyong had a host of top players out due to Ned Gilbert's wedding, but managed just two goals all afternoon.
Creswick started its 150th anniversary celebrations by handing Clunes a 48-point defeat, Waubra got the better of Dunnstown by six goals, Gordon fended off Skipton to win by 16 points and Newlyn beat Springbank by 27 points.
The clash between reigning premiers Beaufort and Carngham-Linton kicked off at 4.30pm and saw the Crows run out massive winners.
Newlyn 9.11 (65) d Springbank 5.8 (38)
Bungaree 4.10 (34) d Buninyong 2.5 (17)
Gordon 15.11 (101) d Skipton 12.13 (85)
Waubra 13.8 (86) d Dunnstown 7.8 (50)
Hepburn 19.15 (129) d Daylesford 5.7 (37)
Rokewood-Corindhap 14.15 (99) d Learmonth 3.3 (21)
Creswick 13.11 (89) d Clunes 6.5 (41)
Beaufort 20.11 (131) d Carngham-Linton 2.6 (18)