The announcement comes on the back of ongoing knee and hip issues which have prevented the 31-year-old from playing this season.

Grigg made 214 AFL appearances - 43 of those for Carlton - and played in every game of the Tigers' premiership campaign.

He began his AFL career with Carlton after being recruited by the Blues via North Ballarat Rebels with pick 19 in the 2006 national draft.

The former St Patrick's College student represented Vic Country under-18s and earned All-Australian selection at the level.

Having played his junior footy at Redan, he is still a familiar face as a spectator watching the Lions in the Ballarat Football League.

The 2017 Richmond premiership player said it had been amazing to play 13 seasons of league football with two great clubs.

"I've loved my football journey, and feel incredibly grateful for the opportunity to play this great game," he said.

"Although it's difficult to make the decision to call time on my own career, it may give the club a chance to provide someone else an opportunity."

The Tigers have been decimated by injuries this season with Toby Nankervis and Jack Ross the latest additions to a casualty list that already includes stars Trent Cotchin (hamstring), Alex Rance (knee) and Jack Riewoldt (knee).

Nankervis (groin) and Ross (ankle) were hurt during Sunday's win over Fremantle in Perth and both face lengthy stints on the sidelines.

Clubs can only add to their list mid-season to fill vacancies created by players retiring or being added to the long-term injury list.

Richmond Tigers football boss Neil Balme said Grigg had been a valuable contributor on and off the field.

"We've loved the way he's gone about his football - always bringing a team-first attitude to the roles we've asked him to play," Balme said.

"He brings a lot of fun to the club, and has built great connections to his teammates, staff and coaches, and we will miss him."