Ms Dark shares more than a passion for physics with Prof Cox - he also loves music and was keyboard player for the British bands D:Ream and Dare before his academic career as a physicist took off and he became well known as a presenter of science programs on the BBC and around the world.

Ms Dark will take to the stage with Prof Cox and fellow Ballarat export Benjamin Northey who will conduct the Melbourne Symphony Orchestra for A Symphonic Universe.

The concert and conversation following, which Ms Dark will host, will bridge the gap between music and science and feature music from the pre-scientific age to highlight how great composers have attempted to understand and explain our place in the universe using music.

Prof Cox will explore the universe and solar system, the big questions of eternity, death, rebirth and existence and more.

"It's a dream come true to share the stage with Brian Cox. He is such a huge figure of modern physics, both his work and the fact he brings physics to people making it accessible, exciting and engaging," she said.

Ms Dark grew up in Ballarat and went to the-then University of Ballarat gaining a Bachelor of Science (physics) and graduate diploma of education and became a physics teacher before following her passion for opera and becoming a renowned mezzo-soprano.

"I was a physics teacher. I'm so excited by physics and I want others to be excited by it. Prof Cox's charisma and knowledge combine to pull that off and make people think this is actually really exciting and want to find out more."

Ms Dark said while many people struggled to see the link between music and physics, they actually shared a close bond.

"The theme of the concert is science and music and the fusion of the two - where the two meet in the universe," she said.

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"There are so many different avenues to go with that. Science produces music - science and maths allow it to occur.

"High level science and music are ways that humans use to find their place in the universe and find themselves within the universe.

"Great physics ideas and music both give me goosebumps and make me teary."

Violinist virtuoso Jack Liebeck will join the MSO to perform the world premiere of Paul Dean's violin concerto A Brief History of Time, which is dedicated to late physicist Professor Stephen Hawking.

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