Police believe a car collided with a truck about 5.20am, with emergency services rushing to the scene following multiple Triple-0 calls.

Upon arrival at the scene, firefighters found the two drivers trapped in their vehicles. Rescue crews worked to free them for some time.

The driver of the truck, a 67-year-old man, was taken to a Ballarat hospital in a serious condition with multiple injuries.

Meanwhile, the driver of the car, a 46-year-old man, was airlifted to the Royal Melbourne Hospital in a serious condition with lower body injuries.

He was trapped in his vehicle for some time.

Remembrance Drive was closed while emergency services worked at the scene.

The road reopened shortly after 9am.

The issue of safety along Remembrance Drive has continued to rear its head in recent years, with a number of serious crashes along the stretch of road.

City of Ballarat councillor Daniel Moloney, now the mayor of the city, called for change in February this year.

"There is a real concern from the community regarding safety," Cr Moloney said at the time.

"It's a growing area and as it continues to grow there's going to be more and more demand on the road. The traffic is only going to increase."

Police are investigating the circumstances surrounding the collision and it remains ongoing.

Anyone who witnessed the collision or who has dash cam footage is urged to contact Crime Stoppers on 1800 333 000 or go to www.crimestoppersvic.com.au

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