It is expected that many people will take Monday off and enjoy a long weekend, with the Australia Day public holiday on Tuesday and forecast warm weather for the next few days.

Highway Patrol Senior Sergeant Stuart Gale said roads across the region were already getting busier with cars towing caravans and people heading off on camping trips.

"We expect to be seeing a lot of people travelling throughout Victoria, enjoying time with family and friends and having a few drinks this weekend," he said.

To reduce the risk of road trauma, police have launched statewide Operation Amity.

It involves highway patrol, uniform and other operational policing units focusing on the biggest contributors to road trauma: speeding, fatigue, distraction and impaired driving.

With the risk of road trauma increased in regional Victoria - where there are higher posted speed limits and longer distances to travel - he encouraged people to travel safely.

"We are seeing time and time again that distraction, inattention, fatigue and speed are factoring in collisions.

"People need to slow down and plan before they make their journey," Senior Sergeant Gale said, adding that people should allow plenty of time to arrive to and from their destinations safely.

"If they are able to, split the driving so they are not fatigued."

Leading into the operation, which began on Friday, police have attended two serious road accidents in the region. The accidents - one at Beaufort and the other at Newtown - resulted in two young people being airlifted to hospital.

Ballarat Highway Patrol is investigating both incidents.

"It just highlights that people need to take care on the roads," he said.

With police catching 233 drink drivers and 141 drug drivers during the same period last year, police will be breath and drug testing at every opportunity.

Senior Sergeant Gale said people needed to be aware of their alcohol consumption and take it into consideration before jumping behind the wheel - both immediately after drinking at night but also the following morning.

"It's a good thing to enjoy time with family and friends but getting home safely the next day is very important."

Local police are also seeing an increase in people not wearing seatbelts. With early evidence indicating that three of the six people killed on the state's roads this year were not wearing seatbelts, Senior Sergeant Gale reiterated the importance of buckling up.

"It is a concern for me. Putting a seatbelt on should be an automatic reflex action when you get into a car. If you're not wearing a seatbelt and are involved in a collision then you will suffer significant and life threatening trauma."

Operation Amity will cover the Australia Day public holiday - it runs from midnight on Friday January, 22 until 11.59pm on Tuesday, January 26.