In a press conference on Sunday morning, Mr Andrews outlined a number of changes would come into effect later this week.

It comes as the state's first dose vaccination rate is almost at 90 per cent. Victoria will this week reach a "significant milestone" on the roadmap to reopening, with 70 per cent of Victorians aged 16 years and over receiving both vaccine doses.

These vaccination rates, in addition to revised Burnet modelling and lower than predicted length of stays in hospital mean further steps will be able to be taken at the 70 per cent double dose that were not previously outlined in the roadmap, including visitors to the home and larger patron caps in certain businesses.

Because of this, Victoria's Chief Health Officer has determined Victoria will be able to move forward in opening up and more restrictions will be eased from 11.59pm on Thursday 21 October.

As part of the changes, up to to 10 people (including dependents) will be able to visit a home each day.

This will apply in both regional and metropolitan Melbourne, though travel is not yet allowed between the two except for permitted reasons. The government said this was to ensure Melburnians don't spread the virus further into regional Victoria until the 80 per cent double vaccinated target is reached.

To ensure visits are done safely, it's highly recommended that Victorians only permit people aged 12 years and over who are fully vaccinated to visit them at home.

Masks will still be required both indoors and outdoors for all Victorians.

In regional Victoria, indoor settings - like restaurants, cafes and gyms - will increase from 10 to 30 people per venue, if everyone is fully vaccinated.

Outdoor venues will increase from 20 to up to 100 people per venue, but only if everyone is fully vaccinated. If vaccination status is unknown, the venue can only have a total of 20 people.

Meanwhile, all students will return to classrooms on Friday, October 22.

These settings will remain in place until Victoria hits the 80 per cent double dose vaccination target, which is predicted to be the first week of November. At this point is expected travel between metro and regional Victoria can resume and further restrictions will be eased.

The announcement was made on a day when 1838 new infections were recorded in the state, bring the number of active cases in the community to 23,376.

Chief Health Officer Brett Sutton said 142 new cases were recorded in regional Victoria on Sunday.

Seven people died, with 777 in hospital and 151 people in intensive care. Further, 94 people are on a ventilator.

Mr Andrews said about 90 per cent of people in hospital and 97 per cent of people in intensive care were not fully vaccinated.

"Nothing tells the story of the power and protection of vaccination more than those stats. People who are very unwell, some of whom are gravely unwell, gasping for air, they are not vaccinated, not fully vaccinated, almost all of them.

"So there is every reason - every reason - to get vaccinated like so many Victorians already have."

He said he was "so proud and deeply grateful" for the high numbers of vaccination.

"But there is still a little way to go. We have to get that 70 number to 80. So if you have a second dose appointment, you need to turn up for that second dose appointment. If you can bring your second dose appointment forward, I would urge you to do that. If you haven't had a first dose yet, every dose matters.

"Even when we pass through these gateways in the next couple of weeks, vaccination is still incredibly important and if we can get to 90 per cent or as high as we can go, that will mean less people in hospital who are really, really sick."

He said it was all about trying to ease the pressure on the health care system and protecting ourselves, families and loved ones.

Mr Andrews conceded there would be a peak in cases in the months ahead and as such, a peak in the number of people in hospital.

"We will see more people lose their lives to this. That will be a terrible tragedy. That will be incredibly difficult for families, for loved ones, for staff in our health system.

"That is why getting vaccinated is so, so important. I can't tell you how proud I am of our state, the resilience, the courage, the compassion and the conviction that Victorians have shown to get this job done. It is quite amazing.

"But just as we have vaccinated in record numbers and in record time, all of us know that this is not over yet. There is still a little way to go and we just have to see this thing through, push on, push through and get vaccinated so that we can hit 80 per cent and beyond so that we can open up, normalise this, look forward to Christmas, the weeks ahead of Christmas and indeed look forward to 2022 with a justified sense of hope and optimism."

For more info on the Roadmap or to book a vaccination visit coronavirus.vic.gov.au/coronavirus-covidsafe-settings.